A person who has Parkinson's may experience some of these more common "hallmark" symptoms: Symptoms of PD vary from person to person, as does the rate of progression. High levels of glutamate, another neurotransmitter, also appear in PD as the body tries to compensate for the lack of dopamine. The PD symptoms of tremor and stiffness occur when the nerve cells fire and there isn't enough dopamine to transmit messages. In PD the nerve cells that produce dopamine are dying. The action of dopamine is opposed by another neurotransmitter called acetylcholine. When the basal ganglia are over- or understimulated the symptoms of tremor, rigidity and slowness of movement occur. The basal ganglia and cerebellum are responsible for ensuring that movement is carried out in a smooth, fluid manner (Fig. Information comes to a central area of the brain called the striatum, which works with the substantia nigra to send impulses back and forth from the spinal cord to the brain. When 80 percent of dopamine is lost, PD symptoms such as tremor, slowness of movement, stiffness, and balance problems occur.īody movement is controlled by a complex chain of decisions involving inter-connected groups of nerve cells called ganglia. For reasons not yet understood, the dopamine-producing nerve cells of the substantia nigra begin to die off in some individuals. Nerve cells in the substantia nigra produce the neurotransmitter dopamine and are responsible for relaying messages that plan and control body movement. Parkinson’s disease (PD) is a degenerative, progressive disorder that affects nerve cells in deep parts of the brain called the basal ganglia and the substantia nigra.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |